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艾尔巴韦/格拉瑞韦治疗1b型儿童慢性丙型肝炎5例疗效分析

Clinical analysis of 5 children cases of chronic hepatitis C genotype 1b treated with elbasvir/grazoprevir
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摘要 目的探讨艾尔巴韦/格拉瑞韦(elbasvir/grazoprevir,EBR/GZR)治疗1b型儿童慢性丙型肝炎(chronic hepatitis C,CHC)的疗效和短期安全性。方法收集2019年1月—2022年3月的基因1b型儿童CHC,给予EBR/GZR治疗12周,停药随访12周的生化学指标、病毒学指标等。主要疗效指标为治疗结束后随访12周时患儿获得持续病学应答(sustained virological response,SVR)和治疗期间的不良反应发生的情况。结果5例儿童CHC,男3例,女2年,平均年龄7.68岁。母亲传播2例、祖父传播1例、父亲传播1例、1例不详。EBR/GZR治疗4周、8周、12周和停药12周的SVR分别为60%、100%、100%、100%。丙氨酸氨基转移酶和天冬氨酸氨基转移酶在治疗4周时均恢复正常。不良反应中,1例出现轻微恶心。结论EBR/GZR治疗儿童1b型CHC的疗效和短期安全性较好。 Objective To explore the efficacy and short-term safety of elbasvir/grazoprevir(EBR/GZR)in the treatment of chronic hepatitis C(CHC)genotype 1b in children.Methods The children infected with genotype 1b hepatitis C virus enrolled from January 2019 to March 2022 were given EBR/GZR treatment for 12 weeks,and followed-up for biochemical and virological indicators for 12 weeks after drug withdrawal.The main efficacy indicators were the sustained virological response(SVR)obtained at the end of the treatment and the occurrence of adverse reactions during the treatment.Results There were 5 CHC children,with 3 males and 2 females,and an average of 7.68 years.There were 2 cases of mother transmission,1 of grandfather transmission,1 of father transmission,and 1 was unknown of the transmission route.The SVR of EBR/GZR treatment for 4,8,12 weeks,and 12 weeks after drug withdrawal were 60%,100%,100%and 100%,respectively.In all patients alanine transferase and aspartate transferase returned to normal after 4 weeks of treatment.For the adverse reactions,there was only 1 case with slightly nausea.Conclusion EBR/GZR was effective and safe for the treatment of CHC genotype 1b children.
作者 刘立 李梅 常丽仙 刘春云 李惠敏 方铭 李俊义 LIU Li;LI Mei;CHANG Li-xian;LIU Chun-yun;LI Hui-min;FANG Ming;LI Jun-yi(Yunnan Infectious Diseases Clinical Medical Center,the Third People’s Hospital of Kunming,Kunming 650041,China;Department of Infectious Diseases,Fuyuan County People′s Hospital,Yunnan 655500,China)
出处 《肝脏》 2023年第9期1041-1043,1067,共4页 Chinese Hepatology
关键词 慢性丙型肝炎 儿童 艾尔巴韦/格拉瑞韦 疗效 安全性 Chronic hepatitis C Children Elbasvir/grazoprevir Curative effect Safety
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  • 1Porto AF, Tormey L, Lim JK. Management of chronic hepa- titis C infection in children[J]. Curr Opin Pediatr, 2012, 24 (1):113-120.
  • 2Ferguson PL, Chiprich J, Smith G, et al. Prevalence of self -reported epilepsy, health care access, and health behav- iors among adults in South Carolina [ J]. Epilepsy Behav, 2008, 13(3): 529-534.
  • 3Bortolotti F, Verucchi G, Camma C, et al. Long -term course ofchronic hepatitis C in children., from viral clearance to end -stage liver disease[J]. Gastroenterology, 2008, 134(7) : 1900 -1907.
  • 4Yeung LT, To T, King SM, et al. Spontaneous clearance of childhood hepatitis C virus infection[ J ]. J Viral Hepat, 2007, 14(11 ) : 797 -805.
  • 5Guido M, Bortolotti F. Viral hepatitis: Treating hepatitis C in children: an open horizon[ J]. Nat Rev Gastroenterol Hepa- tol, 2011, 8(5): 247-248.
  • 6Gonzerez -Peralta RP, Langham MR Jr, Andres JM, et al. Hepatocellular carcinoma in 2 young adolescents with chronic hepatitis C[J]. J Pediatr Gastroenterol Nutr, 2009, 48(5): 630 -635.
  • 7Arshad M, El-Kamary SS, Jhaveri R. Hepatitis C virus in- fection during pregnancy and the newborn period -are they opportunities for treatment? [J]. J Viral Hepat, 2011, 18 (4) : 229 -236.
  • 8Ghamar Chehreh ME, Tabatabaei SV, Khazanehdari S, et aL Effect of cesarean section on the risk of perinatal transmis- sion of hepatitis C virus from HCV- RNA +/HIV- mothers. a meta -analysis[J]. Arch Gynecol Obstet, 2011, 283(2):255 -260.
  • 9Polywka S, Pembrey L, Tovo PA, et al. Accuracy of HCV -RNA PCR tests for diagnosis or exclusion of vertically acquired HCV infection[J]. J Med Virol, 2006, 78(2): 305 -310.
  • 10Serranti D, Buonsenso D, Ceccarelli M, et at. Pediatric hep- atitis C infection to treat or not to treat:, what' s the best for the child? [J]. Eur Rev Med Pharmacol Sci, 2011, 15 (9):1057 -1067.

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