摘要
目的探讨麝香保心丸对药物涂层球囊(DCB)治疗冠脉小血管病变术后再狭窄率、血脂、主要不良心血管事件(MACE)发生率、平板运动实验阳性率的影响。方法选取行DCB治疗小血管病变的104例冠心病患者作为研究对象,随机分为观察组和对照组,每组52例。其中对照组给予常规治疗,观察组在对照组治疗基础上加用麝香保心丸治疗。比较两组术后再狭窄发生率、血脂、平板运动试验阳性率及MACE。结果对照组和观察组每组各50例完成本研究。使用麝香保心丸后,观察组冠脉小血管病变术后再狭窄率为2.00%,低于对照组16.00%,差异有统计学意义(χ^(2)=4.39,P<0.05);观察组在术后1年的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)低于对照组,而高密度脂蛋白胆固醇(HDL-C)高于对照组,差异均有统计学意义(t分别=4.21、2.92、3.51、-2.22,P均<0.05);观察组治疗后平板运动试验阳性率明显低于对照组,差异均有统计学意义(χ^(2)=5.32,P<0.05);观察组MACE事件发生率为6.00%,低于对照组20.00%,差异有统计学意义(χ^(2)=4.33,P<0.05)。结论麝香保心丸能够显著降低DCB治疗冠脉小血管病变术后再狭窄发生率,调整血脂水平和减少MACE发生,降低平板运动试验阳性率。
Objective To investigate the effects of Shexiang Baoxin pills on restenosis rate,blood lipid,the positive rate of exercise treadmill test,and MACE in patients with small coronary artery disease after treating with drug-coated balloons.Methods A total of 104 patients with coronary heart disease who received drug-coated balloon dilatation were selected as study subjects and randomly divided into observation group and control group,52 cases in each group.The control group received conventional treatment,and the observation group was additionally treated with Shexiang Ba⁃oxin pills.The incidence of restenosis,blood lipid,the positive rate of exercise treadmill test,MACE were compared be⁃tween the two groups.Results Totally 50 cases in control group and observation group respectively completed the study.The restenosis rate of small coronary artery in the observation group was 2.00%,which was lower than 16.00%in the control group,and the difference was statistically significant(χ^(2)=4.39,P<0.05).At 1 year after surgery,TC,LDL-C and TG in the observation group were lower than those in the control group,while HDL-C was higher than that in the control group,the difference was statistically significant(t=4.21,2.92,3.51,-2.22,P<0.05).The positive rate of exer⁃cise treadmill test in observation group was significantly lower than that in control group after treatment(χ^(2)=5.32,P<0.05).The incidence of MACE in the observation group was 6.00%,which was lower than 20.00%in the control group,and the difference was statistically significant(χ^(2)=4.33,P<0.05).Conclusion Shexiang Baoxin pills can significantly reduce the restenosis rate after the treatment of small coronary artery disease with drug-coated balloon,adjust blood lipid level,reduce the occurrence of major adverse cardio⁃vascular events(MACE)and the positive rate of ex⁃ercise treadmill test.
作者
喻晖
姚定云
张伟
梅益斌
YU Hui;YAO Dingyun;ZHANG Wei(Department of Cardiology,The People’s Hospital of Lishui,Lishui 323000,China)
出处
《全科医学临床与教育》
2023年第10期876-879,共4页
Clinical Education of General Practice
基金
浙江省中医药科技计划项目(2020ZB306)。
关键词
冠心病
麝香保心丸
再狭窄
冠脉小血管病变
药物涂层球囊
coronary heart disease
Shexiang Baoxin pill
restenosis
small coronary artery disease
drug-coated balloon