摘要
In a series of seven papers in Nature and Nature Medicine,the TRACERx study group presents multi-omic analyses of 421 non-small cell lung cancer(NSCLC)patients,which have yielded a comprehensive map of intratumor heterogeneity(ITH)and lung cancer evolutionary trajectories at an unprecedented level of detail.1–7 The in-depth molecular data,and their subsequent integrated analyses,hold the potential to not only shine light on lung cancer progression but also influence a broad spectrum of scientific disciplines,research fields,and clinical oncology,thereby enhancing our understanding of cancer in general.
基金
This work was supported by the German Research Foundation(DFG,Deutsche Forschungsgemeinschaft)as part of SFB1399(grant ID 413326622)to J.B.
SFB1310(Predictability in Evolution)to A.M.H and the Deutsche Krebshilfe(Mildred Scheel Nachwuchszentrum Grant 70113307)to J.B.
