摘要
Dear Editor,Acute lung injury(ALI)is a significant contributor to the development of acute respiratory distress syndrome(ARDS),which is a severe clinical condition associated with high morbidity and mortality.1 It is increasingly evident that preserving mitochondrial health in alveolar epithelial cells holds great therapeutic potential for ARDS.2 Mitophagy,a cellular process aimed at maintaining mitochondrial health,plays a critical role in this regard.3 Therefore,gaining a comprehensive understanding of the factors that regulate mitophagy in alveolar epithelial cells during ALI could greatly inform the development of future therapeutic approaches for ARDS.
基金
This research was supported by the National Key Research and Development Program of China(No.2021YFF0702000-F.L.)
the National Natural Science Foundation of China(Nos.81770072-F.L.,32070764-F.L.,82170001-X.T.,and 81800087-X.T.)
West China Hospital(No.ZYJC21023-H.W.).The authors gratefully acknowledge support from Jeffrey.A.Whitsett(Cincinnati Children’s Hospital)for reviewing the manuscript,and Yang He(West China Hospital)for providing a confocal microscope.
