摘要
Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 subfamilies.While the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology.
基金
This work is supported by JP20J20669(Y.O.),JP21H04791(A.I.),JP21H05113(A.I.),JPJSBP120213501(A.I.)JPJSBP120218801(A.I.),and JP21H05115(T.S.)from The Japan Society for the Promotion of Science(JSPS)
JPMJPR1331(A.I.),JPMJFR215T(A.I.),JPMJMS2023(A.I.)from the Japan Science and Technology Agency(JST)
JP19gm5910013(A.I.),JP19gm0010004(A.I.and J.A.),JP20am0101095(A.I.),JP22ama121038(A.I.)and JP22zf0127007(A.I.)from the Japan Agency for Medical Research and Development(AMED)
Takeda Science Foundation(A.I.)
The Uehara Memorial Foundation(A.I.)
Tokyo Biochemical Research Foundation(A.I.)
and Daiichi Sankyo Foundation of Life Science(A.I.).F.R.was supported by the Italian Ministry of University and Research through the Department of excellence“Faculty of Sciences”of Scuola Normale Superiore.The research leading to these results also received funding from the Italian Association for Cancer Research(AIRC)under My First AIRC Grant(MFAG)2020-ID.24317 project-P.I.Raimondi Francesco.G.S.and R.B.R.were funded by BMBF-funded de.NBI HD-HuB network,number#031A537C.
