复方鱼腥草合剂联合利巴韦林注射液治疗儿童风热型急性病毒性上呼吸道感染临床研究

Clinical Study on Compound Houttuynia Mixture Combined with Ribavirin Injection for Children with Acute Viral Upper Respiratory Tract Infection of Wind-Heat Type

目的:观察在常规对症治疗措施基础上应用复方鱼腥草合剂联合利巴韦林注射液治疗儿童风热型急性病毒性上呼吸道感染的临床疗效。方法:纳入120例风热型急性病毒性上呼吸道感染患儿,随机分为对照组和观察组各60例。2组均予退热等常规对症措施干预,并以利巴韦林注射液抗病毒治疗,观察组联合复方鱼腥草合剂口服治疗。2组均观察治疗7 d,治疗期间若临床症状消失,即可停药。治疗前后检测血清炎性因子[肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、C-反应蛋白(CRP)],观察退热时间、咳嗽减轻时间、精神改善时间及不良反应发生情况。比较2组的临床疗效。结果:治疗后,观察组临床疗效总有效率高于对照组(P<0.05)。观察组退热时间、咳嗽减轻时间、精神改善时间均较对照组加快(P<0.05)。2组CRP、TNF-α、IL-6水平均低于治疗前(P<0.05),观察组CRP、TNF-α、IL-6水平均低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规对症治疗措施基础上应用复合鱼腥草合剂联合利巴韦林注射液治疗儿童风热型急性病毒性上呼吸道感染,可有效减轻炎性反应,加快临床症状的缓解,缩短病程,用药安全性较好。

Objective:To observe the clinical effect of Compound Houttuynia Mixture combined with Ribavirin Injection based on routine symptomatic treatment measures for children with acute viral upper respiratory tract infection of wind-heat type.Methods:A total of 120 cases of children with acute viral upper respiratory tract infection of wind-heat type were randomly divided into the control group and the observation group,with 60 cases in each group.Both groups were given the measure of bringing down a fever and other routine symptomatic treatment measures and treated with Ribavirin Injection as an antiviral treatment.The observation group was additionally treated with the oral administration of Compound Houttuynia Mixture.Both groups were treated continuously for 7 days,If the clinical symptoms disappear during treatment,the administered drugs can be discontinued.Serum inflammatory factors [tumor necrosis factor-α(TNF-α),interleukin 6(IL-6),and C-reactive protein(CRP)] were detected before and after treatment.The time of abatement of fever,the time of cough remission,the time of vitality improvement,and the incidence of adverse reactions were observed.Clinical effects were compared between the two groups.Results:After treatment,the total clinical effective rate in the observation group was higher than that in the control group(P<0.05).The time of abatement of fever,the time of cough remission,and the time of vitality improvement in the observation group were earlier than those in the control group(P<0.05).The levels of CRP,TNF-α,and IL-6 in the two groups were lower than those before treatment(P<0.05),and the levels of CRP,TNF-α,and IL-6 in the observation group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions(P>0.05).Conclusion:Compound Houttuynia Mixture combined with Ribavirin Injection based on routine symptomatic treatment measures for children with acute viral upper respiratory tract infection of wind-heat type can effectively relieve inflammatory reactions,accelerate the remission of clinical symptoms,and shorten the course of the disease,with good medication safety.