氮杂螺[4.5]三烯酮衍生物的合成研究进展

Advances in the Synthesis of Azaspiro[4.5]trienones

氮杂螺[4.5]三烯酮衍生物作为一种广泛存在于天然产物和活性药物成分中的重要结构单元, 由于其具有优异的结构性能和生物活性, 在有机合成领域得到了广泛应用. 近年来, 通过过渡金属参与、可见光促进、无过渡金属参与和电化学促进等几种方法, 高效构建了含各种官能团的氮杂螺[4.5]三烯酮衍生物. 综述了氮杂螺[4.5]三烯酮合成的最新研究进展, 并对代表性底物及反应机理进行了归纳和讨论.

As one of the most important structural motifs in natural compounds and active pharmaceutical ingredients, aza- spiro[4.5]trienones derivatives have been widely used in the field of organic synthesis due to their excellent structural properties and biological activities. In recent years, several methods, such as transition metal involvement, visible light promotion, transition metal-free involvement and electrochemical promotion, have been used to efficiently construct various functional groups of azaspiro[4.5]trienones. The recent advances in the synthesis of azaspiro[4.5]trienones are reviewed, and the representative substrates and reaction mechanisms are summarized and discussed.