光诱导醇的直接脱羟基衍生化研究进展

Recent Progress in Light-Driven Direct Dehydroxylation and Derivation of Alcohols

由于C_(sp3)—O键键能大的特点,传统还原裂解醇类的方法多涉及间接的活化过程,在温和条件下对醇C_(sp3)—O键直接裂解是一个巨大的挑战.近年来通过光诱导条件直接对其裂解进行脱羟基还原、脱羟基衍生化的策略取得了重大的突破,这些策略相较于传统方法不需要预活化步骤,也能避免传统当量氧化还原剂的使用,具有更好的原子经济性、步骤经济性以及氧化还原经济性.该主题综述文献较少,在此重点综述了光诱导下醇C_(sp3)—O键直接裂解还原及衍生化的进展,从而进一步推动该领域的蓬勃发展.

Conventional methods for the reduction of alcohols mainly deal with the indirect cleavages of C_(sp3)—O bond involving tedious activated steps. In contrast, the more straightforward direct reduction of naturally abundant aliphatic alcohols to alkanes or other reductive derivatives poses a challenge to organic chemists due to the inherently stable and less reactive C_(sp3)—O bond. The development of direct reductive strategies induced by light is of utmost importance due to their atom economy, step economy and redox economy, and many progresses have been made in this area these years. However, very few reviews on this topic has been reported so far. Herein, the recent progress in the light-driven direct deoxygenation of alcohols with emphasis on important advances last ten years is reviewed, which is expected to further promote the vigorous development of this field.