低共熔溶剂1,3-二甲基脲/L-(+)-酒石酸中(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成

Deep Eutectic Solvent of 1,3-Dimethylurea/L-(+)-Tartaric Acid for the Green Synthesis of (E)-2-Styrylquinoline-3-carboxylic Acid Derivatives

利用环境友好且无毒无害的1,3-二甲基脲(DMU)/L-(+)-酒石酸(LTA) (n∶n=7∶3)形成的低共熔溶剂(DES)作为反应介质和催化剂使2-甲基喹啉-3-羧酸与芳醛直接进行有效的乙烯化反应, 成功实现了(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成. 所开发的合成方法具有温和且环境友好的反应条件, 实验操作简便, 后处理简单和收率高等优点, 具有很好的实际应用价值.

A green, efficient and catalyst-free synthesis of (E)-2-styrylquinoline-3-carboxylic acid derivatives via direct olefination of 2-methylquinoline-3-carboxylic acid with aromatic aldehydes has been accomplished successfully by using environmentally benign and non-toxic deep eutectic solvent (DES) of 1,3-dimethylurea (DMU)/L-(+)-tartaric acid (LTA) (n∶n=7∶3) as a dual catalyst and reaction medium. The synthetic strategy has the attractive features such as mild and environmentally benign reaction conditions, experimental simplicity, easy work-up procedure and good yields, which would contribute to the usefulness of this method.