慢性咳嗽与脑血管疾病发生风险的前瞻性队列研究

Chronic cough and risk of cerebrovascular disease:a prospective cohort study

目的探究慢性咳嗽与脑血管疾病发生风险的关联性,为脑血管疾病的早期预防提供流行病学依据。方法自2010年到2012年在贵州省地区,采用多阶段比例分层整群抽样,将符合本研究纳入标准的人群纳入队列,并进行人口学信息、生活方式、疾病史的基线问卷调查。在2016年—2020年随访脑血管疾病发生情况。结果对4804名参与者进行了随访,最终纳入4589名(53.5%为女性)进行统计分析。不同的咳嗽模式影响脑血管疾病的发生风险不同,非慢性咳嗽与不咳嗽人群相比,发生脑血管疾病的风险无统计学意义(P>0.05),慢性咳嗽人群(风险比率为2.00,95%置信区间为1.08~3.69)发生脑血管疾病的风险是不咳嗽人群的2倍。结论慢性咳嗽的人群发生脑血管疾病的风险比不咳嗽人群高。应重视咳嗽的管理及控制,避免迁延为慢性咳嗽,进而降低脑血管疾病的发生风险。

Objective To explore the association between cough patterns and cerebrovascular disease risk,and to provide epidemiological evidence for the early diagnosis and prevention of cerebrovascular disease.Methods During the period from 2010 to 2012 in Guizhou Province,a multi-stage proportional stratified cluster sampling method was used to recruit people with the inclusion criteria of the study into a cohort and a baseline questionnaire for demographic information,lifestyle,and disease history was administered.The incidence of cerebrovascular disease was followed up from 2016 to 2020.Results A total of 4804 subjects were followed up,and 4589(53.5%were female)subjects were enrolled in final investigation.Compared with non-chronic cough group,there was no statistical significance in the risk of cerebrovascular diseases(P>0.05),however,chronic cough(the risk ratio was 2.00 and the 95%confidence interval ranged from 1.08 to 3.69)was twice as likely to develop cerebrovascular disease as non-cough.Conclusions People with chronic cough are more likely to develop cerebrovascular disease than people without cough.More attention to the management and control of cough should be paid to avoid chronic cough,so as to reduce the risk of cerebrovascular diseases.