扶正化浊法治疗动脉粥样硬化研究进展

Research progress of atherosclerosis based on Fuzheng Huazhuo treatment

动脉粥样硬化是一种与饮食、吸烟、肥胖等因素密切相关的,以脂质蓄积为特征的慢性炎症性血管病变,其发病率逐年上升,严重危害人类健康。在现代中医学中,浊邪既是动脉粥样硬化的病理产物又是致病因素,常易导致正虚浊成的病机,因此从扶正化浊入手治疗动脉粥样硬化尤为必要。近年来,随着对肠道菌群代谢产物吲哚-3-丙酸研究的不断加深,发现吲哚-3-丙酸的代谢与扶正化浊的治法具有一定相关性,进一步加强了吲哚-3-丙酸和动脉粥样硬化的联系,也为中医药以吲哚-3-丙酸为靶点,通过扶正化浊法干预吲哚-3-丙酸水平延缓动脉粥样硬化提供新的视角。

Atherosclerosis(AS)is a chronic inflammatory vascular disease characterized by lipid accumulation,which is closely related to diet,smoking,obesity and other factors.Its incidence is increasing year by year,which seriously endangers human health.In modern Chinese medicine,turbidity is not only the pathological product of atherosclerosis but also the pathogenic factor,which often leads to pathogenesis of positive deficiency turbidity.It is particularly necessary to treat atherosclerosis by righting turbidity.In recent years,with deepening of research on indole-3-propionic acid,metabolic product of intestinal flora,it has been found that the metabolism of indole-3-propionic acid has a certain correlation with treatment of Fuzheng Huazhuo,which further strengthens relationship between indole-3-propionic acid and atherosclerosis.It is also the target of indole-3-propionic acid in traditional Chinese medicine.It provides a new perspective to intervene indole-3-propionic acid level to delay atherosclerosis by Fuzheng Huazhuo.