金刚烷胺胶囊联合司来吉兰治疗帕金森病的临床效果

Clinical Effect on Amantadine Capsules Combined with Selegiline in the Treatment of Parkinson’s Disease

目的 观察金刚烷胺胶囊联合司来吉兰治疗帕金森病(PD)的效果。方法 前瞻选取2019年1月至2020年8月在郑州市金水区总医院就诊82例PD患者,依据随机数字表法分为对照组和观察组,各41例。对照组接受常规治疗联合司来吉兰,在此基础上,观察组加用金刚烷胺胶囊。治疗2个月时评估治疗效果。治疗前、治疗2个月时,使用统一PD评分量表(UPDRS)评估并对比两组病情改善情况、认知功能[简易精神状态检查量表(MMES)和蒙特利尔认知评估量表(MoCA)];记录两组不良反应情况。结果 治疗2个月时,两组精神行为、日常活动及运动能力等UPDRS评分较治疗前降低,且观察组低于对照组(P<0.05);治疗2个月时,两组MMES量表、MoCA量表评分较治疗前升高,且观察组高于对照组(P<0.05);两组的不良反应总发生率对比,差异无统计学意义(P>0.05)。结论 金刚烷胺胶囊联合司来吉兰治疗PD,利于改善患者病情及认知功能,且不会增加不良反应,安全性好。

Objective To observe the effect of amantadine capsules combined with selegiline in the treatment of Parkinson’s disease(PD).Methods A total of 82 PD patients admitted to Zhengzhou Jinshui District General Hospital from January 2019 to August 2020 were prospectively selected,they were divided into control group and observation group by random number table method,with 41 cases in each group.The control group was received conventional treatment and selegiline,and the observation group was added with amantadine capsules on this basis,the treatment effect was evaluated after 2 months of treatment.Before treatment and 2 months after treatment,unified PD rating scale(UPDRS)was used to evaluate and compare the improvement of disease condition of the two groups,the mini-mental state examination(MMES)and montreal cognitive assessment scale(MoCA)were used to evaluate and compare the cognitive function of the two groups.The adverse reactions were recorded between the two groups.Results After 2 months of treatment,the UPDRS scores of mental behavior,daily activities and motor ability of both groups were decreased than those before treatment,and the observation group was lower than those of the control group(P<0.05).After 2 months of treatment,the scores of MMES and MoCA in both groups were increased than those before treatment,and the observation group was higher than those of the control group(P<0.05).Compared the total incidence of adverse reactions of both groups,the difference was not statistically significant(P>0.05).Conclusion Amantadine capsules combined with selegiline in the treatment of PD is more conducive to improving disease condition and cognitive function of patients,and it will not increase the adverse reactions and has high safety.