摘要
干细胞源性细胞外囊泡(SC-EVs)是由干细胞分泌的脂质囊泡,在组织再生医学中具有广泛的应用前景。目前已发现SC-EVs能够促进牙槽骨成骨再生,但成骨机制尚不明确。RANKL/RANK/OPG信号通路是调节骨代谢的重要通路,因此该文就RANKL/RANK/OPG信号通路在促进牙槽骨成骨的作用作一综述,为研究SC-EVs的成骨机制提供参考。
Stem cell-derived extracellular vesicles(SC-EVs)are lipid vesicles secreted by stem cells,with prospects for being extensively applied in the field of tissue engineering and regenerative medicine.At present,it has been found that SC-EVs can promote the regeneration of the alveolar bone,but the mechanism of osteogenesis is still unclear.The RANKL/RANK/OPG signaling pathway is essential for regulating the bone metabolism.Therefore,this review summarizes the role of the RANKL/RANK/OPG signaling pathway in promoting osteogenesis of the alveolar bone,providing an insight for investigating the mechanism of osteogenesis mediated by SC-EVs.
作者
黄霞
魏津钿
苏琪
周志迎
项琪
Huang Xia;Wei Jin-tian;Su Qi;Zhou Zhi-ying;Xiang Qi(School of Stomatology,Jinan University,Guangzhou,Guangdong 510632,China;Department of Stomatology,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong 510630,China;Biopharmaceutical Research&Development Center,Jinan University,Guangzhou,Guangdong 510632,China)
出处
《中国现代医学杂志》
CAS
北大核心
2023年第20期60-64,共5页
China Journal of Modern Medicine
基金
国家重点研发计划(No:2022YFC2403100)
广东省重点领域研发计划(No:2022B1111080007)
广州市重点研发计划(No:202103030003)。
关键词
干细胞
细胞外囊泡
牙槽骨
成骨
stem cell
extracellular vesicles
alveolar bone
osteogenesis
