AXIN1和Periostin蛋白与子宫内膜异位症预后或复发的相关研究

Association of AXIN1 and Periostin proteins with prognosis or recurrence of endometriosis

目的探讨体轴发育抑制因子(AXIN1)和骨膜蛋白(Periostin)与子宫内膜异位症预后或复发的关系以及其预测价值。方法纳入2019年2月至2021年2月该院收治的子宫内膜异位症患者78例为研究组,选择同期到该院进行健康体检的健康志愿者24例为对照组。研究组治疗后3个月随访,子宫内膜异位症复发者为复发组(29例),未复发者为未复发组(49例)。采集治疗前研究组和对照组受试人员的血清,并检测血清中AXIN1和Periostin蛋白的表达水平以及相关激素水平。结果研究组血清AXIN1和Periostin蛋白表达水平均高于对照组,差异有统计学意义(P<0.05)。复发组血清AXIN1和Periostin蛋白表达水平、雌二醇水平、孕酮水平、促卵泡激素水平均高于未复发组,差异有统计学意义(P<0.05)。血清AXIN1和Periostin蛋白表达水平与雌二醇水平、孕酮水平、促卵泡激素水平均呈正相关(P<0.05)。AXIN1和Periostin蛋白单向预测子宫内膜异位症复发的灵敏度分别为97.48%和93.50%,特异度分别为95.29%和96.01%。AXIN1和Periostin蛋白联合检测对子宫内膜异位症复发预测的灵敏度96.55%,特异度为95.92%,准确度为96.15%。结论血清AXIN1和Periostin蛋白的检测可作为预测子宫内膜异位症复发的潜在生物标志物。

Objective To investigate the relationship between AXIN1 and Periostin and prognosis or recurrence of endometriosis and its predictive value.Methods Seventy-eight patients with endometriosis admitted to Hengshui People′s Hospital from February 2019 to February 2021 were included as the study group,and 24 healthy volunteers admitted to Hengshui People′s Hospital as the control group.In the study group,patients with recurrent endometriosis were in the recurrent group(29 cases)and those without recurrent endometriosis were in the non-recurrent group(49 cases).The sera of the study group and the control group were collected before treatment,and the protein levels of AXIN1 and Periostin and related hormone levels in the sera were tested.Results The serum expression levels of AXIN1 and Periostin in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The expression levels of AXIN1 and Periostin protein,estradiol,progesterone and follicle-stimulating hormone in the relapsed serum were higher than those in the control group,and the differences were statistically significant(P<0.05).The expression levels of AXIN1 and Periostin proteins in serum were positively correlated with estradiol levels,progesterone levels,and follicle-stimulating hormone levels(P<0.05).The sensitivity and specificity of AXIN1 and Periostin to predict the recurrence of endometriosis were 97.48%and 93.50%,respectively,and 95.29%and 96.01%,respectively.The sensitivity,specificity,and accuracy of AXIN1 and Periostin combined to predict the recurrence of endometriosis were 96.55%,95.92%,and 96.15%.Conclusion Serum tests for AXIN1 and Periostin can be used as potential biomarkers to predict the recurrence of endometriosis.