氧化三甲胺在动脉粥样硬化中的研究进展

Research progress of trimethylamine N-oxide in atherosclerosis

氧化三甲胺是肠道菌群的代谢产物之一,通过多条信号通路影响冠状动脉粥样硬化性疾病的病理过程,具有促进血管内皮细胞损伤、参与血管壁脂质沉积、促进炎症发生发展并刺激平滑肌细胞衰老、迁移等作用。研究表明,通过介导氧化三甲胺的代谢及相关信号通路的激活,可以预防并治疗动脉粥样硬化性疾病。文章将围绕氧化三甲胺参与动脉粥样硬化的作用机制进行简要综述,以期为动脉粥样硬化性疾病的防治提供新的研究思路。

Intestinal bacteria produce metabolites such as trimethylamine N-oxide(TMAO),which have been found to impact the pathological process of coronary artery atherosclerotic disease through various signaling pathways.TMAO has been shown to induce vascular endothelial cell damage,contribute to lipid deposition in the vascular wall,promote inflammation,and stimulate smooth muscle cell aging and migration.Research suggests that modulation of TMAO metabolism and associated signaling pathways may offer potential therapeutic interventions for the prevention and treatment of atherosclerotic disease.This article will provide a brief overview of the TMAO mechanism in atherosclerosis,offering new research insights for the prevention and treatment of this disease.