MRTF-A在动脉粥样硬化病变中的研究进展

Research progress of MRTF-A in atherosclerotic lesions

动脉粥样硬化是心血管事件发生的重要因素。相关流行病学调查显示,近几年中国动脉粥样硬化性心血管疾病负担快速而显著增加,给国家公共卫生问题带来重大挑战。心肌素相关转录因子A(MRTF-A)在动脉粥样硬化发展进程中发挥着重要作用,包括参与炎症反应、促进粥样硬化进程中脂质积聚及促进血管平滑肌细胞表型转化等,探索MRTF-A在动脉粥样硬化病变中的研究进展对于寻找新的治疗靶点具有重要意义。文章就MRTF-A在动脉粥样硬化病变过程中的作用进行综述,可为冠状动脉粥样硬化的靶向治疗提供参考。

Atherosclerosis is an important factor in cardiovascular events.Relevant epidemiological surveys show that the burden of atherosclerotic cardiovascular disease in China has increased rapidly and significantly in recent years,which has brought major challenges to China's public health problems.Myocardin-related transcription factor-A(MRTFA)plays an important role in the development of atherosclerosis,including participating in inflammatory responses,promoting lipid accumulation,and phenotypic transformation of vascular smooth muscle cells(VSMC)in the process of atherosclerosis,and exploring the correlation between MRTF-A and atherosclerosis is of great significance for finding new therapeutic targets.This article reviews the role of MRTF-A in the process of atherosclerosis lesions,which can provide a reference for targeted therapy of coronary atherosclerosis.