摘要
近年来,分子生物学取得的重大进展为胃癌治疗提供了新的靶向治疗策略。Claudin18作为细胞间紧密连接的重要结构蛋白,其亚型Claudin18.2(CLDN18.2)特异性表达于分化的胃上皮细胞,为胃癌患者提供了新的治疗靶点。本文旨在系统梳理CLDN18.2在胃癌基础和临床研究领域的最新进展,以期为临床实践提供参考。
In recent years,significant advancements in molecular biology have paved the way for novel targeted therapeutic strategies for gastric cancer treatment.Claudin18,which is an important structural protein involved in tight junctions between cells,and its subtype Claudin18.2(CLDN18.2),which is specifically expressed in differentiated gastric epithelial cells,have emerged as novel therapeutic targets for patients with gastric cancer.This article aims to systematically review the latest developments in CLDN18.2 research in the fields of basic and clinical gastric cancer studies to provide a reference for clinical practice.
作者
李澔
叶显辉
周俊杰
李晓芬
LI Hao;YE Xianhui;ZHOU Junjie;LI Xiaofen(Division of Abdominal Tumor Multimodality Treatment,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China;Colorectal Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《肿瘤防治研究》
CAS
2023年第10期1022-1028,共7页
Cancer Research on Prevention and Treatment
