摘要
视神经脊髓炎谱系疾病(neuromyelitis optic spectrum disease,NMOSD)是一种中枢神经系统炎性脱髓鞘疾病,主要影响视神经和脊髓,其特征是水通道蛋白-4自身抗体的存在(aquaporin-4,AQP4)。NMOSD可出现多种形式的运动障碍表现,包括继发性发作性运动障碍(secondary paroxysmal dyskinesia,sPxD)表现,但sPxD通常出现在疾病恢复期。以发作性运动障碍为首发症状的病例罕见报道。本文分享1例以发作性运动障碍起病的NMOSD病例,该症状持续近1个月才出现肢体无力等其他症状。正确认识发作性运动障碍和NMOSD的关系有助于疾病早期诊断和治疗。
Neuromyelitis optica spectrum disease(NMOSD)is an inflammatory demyelinating disease of the central nervous system that preferentially affects the optic nerves and spinal cord,characterized by the presence of aquaporin-4 au-toantibodies.NMOSD can result in a variety of forms of dyskinesia,including secondary paroxysmal dyskinesia(sPxD),but sPxD usually occurs during the recovery period.Cases with PxD as the initial presentation have rarely been reported.We present a case of NMOSD starting as PxD,which lasted for nearly a month before the onset of limb weakness and other symptoms.A correct understanding of the relationship between PxD and NMOSD will contribute to the early diagnosis and treatment of the disease.
作者
李苗苗
孙虹
张慧
李渊
徐希彤
毛薇
LI Miaomiao;SUN Hong;ZHANG Hui(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
出处
《中风与神经疾病杂志》
CAS
2023年第10期939-941,共3页
Journal of Apoplexy and Nervous Diseases