以发作性运动障碍为首发症状的视神经脊髓炎谱系疾病1例报告并文献复习

Neuromyelitis optica spectrum disease starting as paroxysmal dyskinesia:A case report and literature review

视神经脊髓炎谱系疾病(neuromyelitis optic spectrum disease,NMOSD)是一种中枢神经系统炎性脱髓鞘疾病,主要影响视神经和脊髓,其特征是水通道蛋白-4自身抗体的存在(aquaporin-4,AQP4)。NMOSD可出现多种形式的运动障碍表现,包括继发性发作性运动障碍(secondary paroxysmal dyskinesia,sPxD)表现,但sPxD通常出现在疾病恢复期。以发作性运动障碍为首发症状的病例罕见报道。本文分享1例以发作性运动障碍起病的NMOSD病例,该症状持续近1个月才出现肢体无力等其他症状。正确认识发作性运动障碍和NMOSD的关系有助于疾病早期诊断和治疗。

Neuromyelitis optica spectrum disease(NMOSD)is an inflammatory demyelinating disease of the central nervous system that preferentially affects the optic nerves and spinal cord,characterized by the presence of aquaporin-4 au-toantibodies.NMOSD can result in a variety of forms of dyskinesia,including secondary paroxysmal dyskinesia(sPxD),but sPxD usually occurs during the recovery period.Cases with PxD as the initial presentation have rarely been reported.We present a case of NMOSD starting as PxD,which lasted for nearly a month before the onset of limb weakness and other symptoms.A correct understanding of the relationship between PxD and NMOSD will contribute to the early diagnosis and treatment of the disease.