人眼表微生物群与眼表疾病研究进展

Research progress of human surface microbiota and ocular surface diseases

眼表微生物群是人体眼表微环境的一部分,在维持其稳定中占据重要作用。许多研究对于健康与疾病状态下眼表微生物群的组成进行探究,但研究结果基于内外因素的不同而存在差异,且微生物失调与疾病之间的关系也尚未明确。近年来,随着肠道微生物与全身性疾病的研究不断深入,眼科研究者们也从中获得了一些启发,对眼表微生物群与眼表非感染性疾病的关系有了更进一步的探讨。本文将对正常眼表核心微生物群、眼部及全身性疾病眼表微生物群的变化进行综述,并讨论微生物失调引起疾病的可能机制,希望对未来眼表微生物群的进一步研究提供参考依据。

The ocular surface microbiota is a part of the human ocular surface microenvironment and is critical to its stability.Many studies have explored the composition of the ocular surface microbiota in health and disease,but the research results are different based on internal and external factors,and the relationship between microorganism dysbiosis and diseases also remains unclear.As the research on intestinal microorganisms and systemic diseases has intensified in recent years,ophthalmic researchers have been inspired to further explore the relationship between ocular surface microbiota and non-infectious ocular surface diseases.Therefore,this article will review the core microbiota of the normal ocular surface as well as alterations in ocular surface microbiota in ocular and systemic diseases,and discuss the possible mechanisms of diseases caused by microorganism dysbiosis,hoping to provide a reference for future studies in ocular surface microbiota.