基于铁死亡与染色质修饰途径探讨中医药在神经系统疾病中的调控研究进展

To explore the regulation of traditional Chinese medicine against nervous system diseases based on ferroptosis and chromatin modification

随着人口老龄化的加速,阿尔兹海默病、帕金森病、抑郁症等神经系统疾病不仅对患者的身心健康造成影响,更为家庭和社会带来很大负担。近年来研究发现铁死亡与神经系统疾病关系密切,而染色质修饰可影响铁死亡的发生发展过程。中医药治疗神经系统疾病具有多靶点、多途径等优势,基于染色质修饰介导铁死亡来探索中医药对于神经系统疾病的调控机制将成为研究中医药治疗神经系统疾病的新方向。文章通过阐述铁死亡与染色质修饰途径之间的相互作用,为中医药治疗神经系统疾病研发提供理论基础。

As the aging population grows,Alzheimer's disease(AD),Parkinson's disease(PD),depression(MDD)and other neurological diseases not only affect physical and mental health,but also bring a great burden to the family and society.In recent years,studies have found that ferroptosis is closely related to nervous system diseases,and chromatin modification can affect the progressof ferroptosis.Traditional Chinese medicine has the advantages of multiple targets and multiple pathways in the treatment of nervous system diseases.Exploring the regulatory mechanism of traditional Chinese medicine on nervous system diseases based on chromatin modification-mediated ferroptosis will become a new direction of research on the treatment of nervous system diseases by traditional Chinese medicine.This article reviewed the interaction between ferroptosis and chromatin modification to provide a theoretical basis for the research and development of traditional Chinese medicine in the treatment of neurological diseases.