肠内营养联合益生菌治疗重症肺炎患者的效果及对其血清炎症因子水平的影响

Effect of Enteral Nutrition Combined with Probiotics in the Treatment of Patients with Severe Pneumonia and Its Effect on Serum Inflammatory Factor Levels

目的:研究肠内营养联合益生菌治疗重症肺炎患者的效果及对其血清炎症因子水平的影响。方法:选择2022年1月—2023年1月大冶市人民医院收治的156例重症肺炎患者,采用简单随机法将其分为对照组(接受肠内营养治疗)和观察组(接受肠内营养联合益生菌治疗),各78例。比较两组临床疗效、营养状况及血清炎症因子水平。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。干预前,两组血红蛋白(Hb)、血清白蛋白(ALB)和前白蛋白(PAB)比较,差异无统计学意义(P>0.05);干预2周后,两组Hb、ALB和PAB水平均高于干预前,且观察组显著高于对照组,差异有统计学意义(P<0.05)。干预前,两组血清炎症因子水平比较,差异无统计学意义(P>0.05);干预2周后,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)和单核细胞趋化蛋白1(MCP-1)水平均低于干预前,且观察组显著低于对照组,差异有统计学意义(P<0.05)。结论:肠内营养联合益生菌治疗能显著提升重症肺炎患者的临床效果,改善其营养状况且能降低其炎症因子水平。

Objective:To study the effect of enteral nutrition combined with probiotics on the level of serum inflammatory factors in patients with severe pneumonia.Method:A total of 156 patients with severe pneumonia admitted to Daye People's Hospital from January 2022 to January 2023 were selected and divided into control group(receiving enteral nutrition treatment)and observation group(receiving enteral nutrition combined with probiotics treatment)by simple random method,with 78 cases in each group.The clinical efficacy,nutritional status and serum levels of inflammatory factors were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before intervention,there were no significant differences in hemoglobin(Hb),serum albumin(ALB)and prealbumin(PAB)between the two groups(P>0.05).After 2 weeks of intervention,the levels of Hb,ALB and PAB in both groups were higher than those before intervention,and the levels in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Before intervention,there were no significant differences in serum inflammatory factors between the two groups(P>0.05).After 2 weeks of intervention,the levels of interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)and monocyte chemotactic protein 1(MCP-1)in both groups were lower than those before intervention,and the levels in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Enteral nutrition combined with probiotics can significantly improve the clinical efficacy of patients with severe pneumonia,improve their nutritional status and reduce the level of inflammation.