射频消融术在原发性肝癌术后复发患者中的应用价值

Application Value of Radiofrequency Ablation in the Patients with Postoperative Recurrence of Primary Liver Cancer

目的:探究射频消融术在原发性肝癌术后复发患者中的应用价值。方法:选取2019年1—12月福建医科大学附属泉州第一医院收治的80例原发性肝癌术后复发患者。根据随机数表法将其分为对照组和观察组,各40例。对照组给予手术切除治疗,观察组给予射频消融术治疗。比较两组手术效果、并发症、术后住院时间,术后1年、2年、3年的生存率,术前及术后1个月、3个月相关指标、生存质量。结果:两组病灶均完全消融或切除。观察组术后住院时间显著短于对照组,并发症发生率显著低于对照组,差异有统计学意义(P<0.05)。两组术后1年、2年、3年生存率比较,差异无统计学意义(P>0.05)。术前及术后1个月、3个月,两组高尔基体蛋白73(GP73)、甲胎蛋白(AFP)及甲胎蛋白异质体(AFP-L3)水平比较,差异无统计学意义(P>0.05)。术后1个月、3个月,观察组躯体良好和能力、心理良好、因癌造成的艰难、社会良好及恶心评分均显著高于对照组,差异有统计学意义(P<0.05)。结论:射频消融术与手术切除治疗对原发性肝癌术后复发患者疾病相关血液指标的影响相同,但射频消融术对于生存质量的改善效果相对更好,因此在原发性肝癌术后复发患者中的应用价值相对更高。

Objective:To investigate the application value of radiofrequency ablation in the patients with postoperative recurrence of primary liver cancer.Method:A total of 80 patients with postoperative recurrence of primary liver cancer admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from January to December 2019 were selected.They were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with surgical resection and the observation group was treated with radiofrequency ablation.The surgical results,complications,postoperative hospitalization time,survival rate of 1,2 and 3 years after surgery,relevant indexes and quality of life before and 1 and 3 months after surgery were compared between the two groups.Result:The lesions in both groups were completely ablated or resected.The postoperative hospitalization time in the observation group was significantly shorter than that in the control group,and the incidence of complications was significantly lower than that in the control group,the differences were statistically significant(P<0.05).There were no significant differences in survival rates 1,2 and 3 years after surgery between the two groups(P>0.05).There were no significant differences in the levels of Golgi protein 73(GP73),alpha-fetoprotein(AFP)and alpha-fetoprotein heteroplasmon(AFP-L3)between the two groups before surgery and 1 and 3 months after surgery(P>0.05).At 1 month and 3 months after surgery,the scores of good physical condition and ability,psychological well-being,hardship caused by cancer,social well-being and nausea in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Radiofrequency ablation and surgery resection treatment have the same effect on disease-related blood indexes in patients with postoperative recurrence of primary liver cancer,but radiofrequency ablation has a relatively better effect on improving quality of life,so it has a relatively higher application value in patients with postoperative recurrence of primary liver cancer.