某院复发性阿弗他溃疡药物利用评价

Drug Utilization Evaluation of Drugs for the Treatment of Recurrent Aphthous Ulcer in a Hospital

目的促进复发性阿弗他溃疡(RAU)治疗药物的临床合理使用。方法回顾性分析南京大学医学院附属口腔医院2020年至2022年收治的RAU患者的病历资料,收集药品种类、规格、数量、金额等用药情况。采用用药金额分析法、用药频度分析法和描述性分析法评价RAU治疗药物的用药金额、用药频度(DDDs)、限定日费用(DDC)、排序比(B/A)、药物利用指数(DUI)及复合年均增长率(CAGR)。结果2020年至2022年,该院应用了32种RAU治疗药物,包括全身用药(53.12%)、局部外用药(37.50%)、中成药(9.38%);多数RAU治疗药物的销售金额和DDDs均呈负增长;销售金额和DDDs较大的品种为局部应用激素类软膏、含漱液、免疫调节剂及中成药;DDC较低的药物主要有醋酸泼尼松片、复方氯己定含漱液等;多数药物的B/A大于1;多数药物DUI为1。结论该院RAU治疗药物的应用基本合理,可为临床治疗RAU用药提供参考。

Objective To promote the rational use of drugs for the treatment of recurrent aphthous ulcer(RAU)in the clinic.Methods A retrospective analysis was conducted on the medical records of RAU patients admitted to the Affiliated Hospital of Nanjing University Medical School from 2020 to 2022,and drug types,specifications,quantities,and consumption sum were collected.The consumption sum of medication,defined daily dose system(DDDs),defined daily cost(DDC),sorting ratio(B/A),drug utilization index(DUI),and compound annual growth rate(CAGR)of the RAU treatment drugs by medication consumption sum analysis,DDDs analysis,and descriptive analysis.Results From 2020 to 2022,32 kinds of RAU treatment drugs were used in the hospital,including systemic drugs(53.12%),topical and extmal drugs(37.50%),and Chinese patent drug(9.38%).The consumption sum and DDDs of most RAU treatment drugs showed negative growth.The varieties with large consumption sum and DDDs were topical hormone ointment,gargle,immunomodulator and Chinese patent drugs.The drugs with lower DDC mainly included Prednisone Acetate Tablets,Compound Chlorhexidine Gargle,etc.Most drugs had a B/A>1,and most drugs had a DUI of 1.Conclusion The application of RAU treatment drugs in this hospital is basically reasonable,which can provide a reference for the clinical medication of RAU.