藤黄健骨胶囊联合西药治疗骨质疏松症Meta分析

Meta-analysis of Tenghuang Jiangu Capsules Combined with Western Medicine in the Treatment of Osteoporosis

目的 对藤黄健骨胶囊治疗骨质疏松症(Osteoporosis,OP)的有效性及安全性进行系统评价和Meta分析。方法 通过中国维普、知网、万方及外文数据库PubMed检索从建库—2023年1月的文献,查找藤黄健骨胶囊治疗OP的随机对照试验。对纳入的文献进行数据提取及方法学质量评价,采用Revman 5.3软件进行Meta分析。结果 最终纳入7篇文献结论,共纳入7项随机对照试验。Meta分析结果显示:治疗有效率[RR=1.22,95%CI(1.12,1.32),P<0.000 01],腰椎骨密度[MD=0.06,95%CI(0.04,0.08),P<0.000 01]、股骨颈骨密度[MD=0.07,95%CI(0.05,0.08),P<0.000 01]、Ward三角骨密度[MD=0.08,95%CI(0.06,0.10),P<0.000 01]、VAS评分[MD=-1.27,95%CI(-1.41,-1.133),P<0.000 01],不良反应发生率[RR=0.42,95%CI(0.15,1.13),P=0.09]。结论 藤黄健骨胶囊联合西药治疗OP能更有效地缓解患者疼痛,提高治疗有效率,提高患者骨密度,且安全性好。但本研究结果仍需更多双盲、多样本、多中心的研究来进一步证实。

Objective To conduct a systematic review and Meta-analysis of the efficacy and safety of Tenghuang Jiangu capsule in the treatment of osteoporosis.Methods CNKI,VIP,Wanfang and PubMed databases were searched for randomized controlled trials(RCT) of Tenghuang Jiangu capsules in the treatment of osteoporosis from the establishment of the databases to January 2023.Data extraction and methodological quality assessment were performed on the included studies.Revman 5.3 software was used for Meta-analysis.Results A total of 7 literature conclusions and 7 randomized controlled trials were included.Meta-analysis results showed that Effective rate [RR=1.22,95% CI(1.12,1.32),P<0.000 01],lumbar spine bone mineral density [MD=0.06,95% CI(0.04,0.08),P<0.000 01],femoral neck bone mineral density [MD=0.07,95% CI(0.05,P<0.000 01)],P<0.08),Ward's triangle bone mineral density [MD=0.08,95% CI(0.06,0.10),P<0.000 01],VAS score [MD=-1.27,95% CI(-1.41,-1.133),P<0.000 01],Incidence of adverse reactions [RR=0.42,95% CI(0.15,1.13),P=0.09].Conclusion Tanghuang Jiangu capsule combined with Western medicine in the treatment of osteoporosis can more effectively relieve pain,improve the treatment efficiency,improve bone mineral density,and has good safety.However,the results of this study still need to be further confirmed by more double-blind,multi-sample and multi-center studies.