靛红杂合体的抗菌活性研究进展

Current Scenario of Isatin Hybrid with Antibacterial Potential

内源性物质靛红广泛存在于自然界中,具有生物活性谱广、毒性低和可修饰位点多等优点,是生物活性物质中的常见结构骨架。靛红类化合物可与包括DNA旋转酶、拓扑异构酶Ⅳ、丝状温度敏感蛋白Z和青霉素结合蛋白在内的多个靶点结合,具有潜在的抗菌活性。其中,靛红杂合体可同时作用于多个靶点,对克服耐药性和拓展抗菌谱具有独特的优势。因此,靛红杂合体在抗菌领域引起了药物化学家的关注。本文将综述2018—2022年间所发展的具有潜在抗菌活性的靛红杂合体的最新研究进展,为进一步研究提供参考。

The naturally occurring chemical isatin is a frequent structural skeleton in bioactive compounds and has a wide range of bioactivity,low toxicity,and several changeable sites.Isatin compounds could act on multiple targets including DNA gyrase,topoisomerase IV,filamentous temperature sensitive protein Z,and penicillin-binding protein.Therefore,isatin compounds have potential activities against a variety of pathogenic bacteria,including drugresistant forms.Among them,isatin hybrids have the potential to act on multiple targets at the same time,which has unique advantages in overcoming drug resistance and expanding the antibacterial spectrum.As a result,medicinal chemists working in the field of antibacterials have been interested in isatin hybrids.In order to serve as a guide for future research,we will highlight the most recent advancements in the study of isatin hybrids that have been developed between 2018 and 2022 and may have antibacterial activity.