中草药对铜绿假单胞菌群体感应系统抑制作用的研究进展

Research Progress on Inhibition of Chinese Herbal Medicine on Quorum Sensing System of Pseudomonas aeruginosa

铜绿假单胞菌是临床常见的一种条件致病菌,其群体感应(QS)系统负责调控其致病因子的表达。因抗生素滥用,细菌的耐药性已经成为了临床治疗面临的一大难题。由于很多研究表明中草药中有许多有效活性成分可以抑制群体感应系统,从而控制铜绿假单胞菌相关毒力因子的表达。本文介绍了铜绿假单胞菌QS系统的组成和群体感应抑制剂的抑制机制,并重点综述了中草药主要有效活性成分对铜绿假单胞菌QS系统抑制作用的研究进展,以此为从中草药中筛选出安全有效的铜绿假单胞菌群体感应抑制剂,解决院内铜绿假单胞菌继发感染和克服细菌耐药问题提供参考。

Pseudomonas aeruginosa is a common opportunistic pathogen in clinical practice,and its quorum sensing(QS)system is responsible for regulating the expression of pathogenic factors.Due to the overuse of antibiotics,bacterial resistance has become a major problem in clinical treatment.Many studies have shown that many active ingredients in Chinese herbal medicine can inhibit the quorum sensing system,thus controlling the expression of Pseudomonas aeruginosa related virulence factors.In order to identify safe and efficient Pseudomonas aeruginosa quorum sensing inhibitors from Chinese herbal medicine,the composition of the QS system of Pseudomonas aeruginosa and the inhibition mechanism of quorum sensing inhibitors were introduced in this article.To provide a reference for solving secondary infection of Pseudomonas aeruginosa in hospitals and overcoming bacterial drug resistance,the research progress of the inhibition effect of the main active components of Chinese herbal medicine on the QS system of Pseudomonas aeruginosa was also reviewed.