胱抑素C在特发性肺纤维化中的价值及与肺功能的关系

The value of cystatin C in idiopathic pulmonary fibrosis and its relationship with pulmonary function

目的:探讨血清胱抑素C(CysC)在特发性肺纤维化(IPF)患者稳定期和病情加重期的水平变化,研究其潜在的价值以探讨CysC水平变化与肺功能之间的关系。方法:共纳入30例IPF患者(稳定期17例,加重期13例)和15例健康受试者。检测研究对象的肺功能指标、C-反应蛋白(CRP)、CysC水平。结果:稳定期IPF及加重期IPF患者血清CysC水平均高于对照组,差异有统计学意义(P<0.001),但两组特发性肺纤维化组间CysC水平差异无统计学意义(P>0.05)。特发性肺纤维化患者中血清CysC水平与血清CRP水平呈正相关(r=0.568,P<0.01);CysC水平与FVC%pred呈负相关(r=-0.438,P<0.05)。结论:研究结果显示,稳定期IPF组及加重期IPF组CysC水平均升高,CysC水平的升高可能与IPF患者的肺功能下降和炎症反应有关。

Objective:The purpose of the study is to determine the level changes of serum cystatin C(CysC)during the stable and exacerbation periods in patients with idiopathic pulmonary fibrosis(IPF)and to investigate the potential value and to explore the relationship between changes in CysC levels and lung function.Methods:A total of 30 IPF patients(17 stable,13 exacerbation)and 15 healthy subjects were included.Pulmonary function indicators,C-reactive protein(CRP),and CysC levels were tested in the study subjects.Results:Serum CysC levels were higher in stable IPF and aggravated IPF than in the control group(P<0.001),but there was no significant difference in CysC levels between the two groups of idiopathic pulmonary fibrosis(P>0.05).Serum CysC levels were positively correlated with serum CRP levels in patients with idiopathic pulmonary fibrosis(r=0.568,P<0.01);CysC levels were negatively correlated with FVC%pred(r=-0.438,P<0.05).Conclusion:The results showed that CysC levels increased in both stable IPF and aggravated IPF groups,and the increase in CysC level may be related to the decrease of lung function and inflammatory response in IPF patients.