启阳胶囊对肾虚血瘀型糖尿病阳痿患者血清NGF、BDNF、VEGF表达水平的影响研究

Study on the Effect of Qiyang Capsule on the Expression Levels of NGF,BDNF and VEGF in Serum of Diabetic Impotence Patients with Kidney Deficiency and Blood Stasis Type

目的:观察启阳胶囊治疗肾虚血瘀型糖尿病阳痿疗效,探索更为安全有效的中医治疗方案,通过比较启阳胶囊与常规治疗的疗效差异,得出肾虚血瘀型糖尿病阳痿最有效治疗方法,探索其作用机制。方法:本研究按照诊断标准、纳入标准和排除标准选取80例肾虚血瘀型糖尿病阳痿患者,随机分为:启阳胶囊组、常规治疗组,各组均为40例。对比2组患者疗效、中医证候积分、脑源性神经营养因子(BDNF)、神经生长因子(NGF)及血管内皮生长因子(VEGF)水平。结果:启阳胶囊组总有效率95.00%明显优于常规治疗组,差异有统计学意义(P<0.05)。治疗后,2组患者IIEF-5评分均较治疗前提高,中医证候积分评分较治疗前降低,启阳胶囊组IIEF-5评分明显高于常规治疗组,中医证候积分评分低于常规治疗组,差异有统计学意义(P<0.05)。治疗后,2组患者NGF、BDNF、VEGF表达水平均较治疗前提高,启阳胶囊组NGF、BDNF、VEGF表达水平明显高于常规治疗组,差异有统计学意义(P<0.05)。治疗后,2组患者FBG、2hPBG、HbA1c表达水平均较治疗前下降,启阳胶囊组FBG、2hPBG、HbA1c表达水平明显低于常规治疗组,差异有统计学意义(P<0.05)。结论:西地那非片与启阳胶囊联合治疗肾虚血瘀型糖尿病阳痿能够提高疗效,其中作用机制在于改善NGF、BDNF、VEGF表达水平。

Objective To observe the efficacy of Qiyang capsule in treating renal deficiency and blood stasis type diabetes impotence,explore a more safe and effective TCM treatment plan,by comparing the efficacy difference between Qiyang capsule and conventional treatment,get the most effective treatment of renal deficiency and blood stasis type diabetes impotence,explore its mechanism of action.Methods In this study,80diabetic impotence patients with kidney deficiency and blood stasis type were selected according to the diagnostic criteria,inclusion criteria and exclusion criteria,and were randomly divided into the Qiyang capsule group and conventional treatment group,with 40cases in each group.The efficacy,TCM syndrome score,brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)and vascular endothelial growth factor(VEGF)levels of the two groups were compared.Results The total effective rate of 95.00%in Qiyang capsule group was significantly better than that in the conventional treatment group,and the difference was statistically significant(P<0.05).After treatment,the IIEF-5score of the 2groups was higher than that before treatment,while the TCM syndrome score was lower than that before treatment.The IIEF5score of Qiyang capsule group was significantly higher than that of conventional treatment group,while the TCM syndrome score of Qiyang Capsule group was lower than that of conventional treatment group,with statistical significance(P<0.05).After treatment,the expression levels of NGF,BDNF and VEGF in 2groups were higher than those before treatment,and the expression levels of NGF,BDNF and VEGF in Qiyang capsule group were significantly higher than those in conventional treatment group,with statistical significance(P<0.05).After treatment,the expression levels of FBG,2hPBG and HbA1c in 2groups were decreased compared with before treatment,and the expression levels of FBG,2hPBG and HbA1c in Qiyang capsule group were significantly lower than those in conventional treatment group,with statistical significance(P<0.05).Conclusion Sildenafil tablet combined with Qiyang capsule in the treatment of kidney deficiency and blood stasis type diabetic impotence can improve the curative effect,the mechanism of which is to improve the expression levels of NGF,BDNF and VEGF.