祛痰利肺汤联合噻托溴铵吸入治疗慢性阻塞性肺疾病疗效观察

Observation on Efficacy of Qutan Lifei Decoction combined with Tiotropium Bromide Inhalation in the Treatment of Patients with Chronic Obstructive Pulmonary Disease

目的:研究祛痰利肺汤联合噻托溴铵吸入治疗慢性阻塞性肺疾病(COPD)患者的疗效。方法:选取2020年1月~2022年1月我院收治的112例COPD患者作为研究对象,随机分为对照组(n=56)与观察组(n=56),对照组使用噻托溴铵吸入治疗,观察组在对照组的基础上联合祛痰利肺汤治疗,比较两组临床疗效、中医症状积分、肺功能、炎症因子、不良反应发生率等。结果:治疗后,两组各项中医症状积分均降低,且观察组明显低于对照组(P<0.05);观察组临床总有效率(98.21%)高于对照组(85.71%,P<0.05);治疗后,观察组潮气量(VT)、肺总量(TLC)、用力肺活量(FVC)、第1秒用力呼气容积占预计值百分比(FEV_(1)%pred)均明显高于对照组(P<0.05);治疗后,观察组干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)水平明显低于对照组(P<0.05);两组不良反应发生率比较无明显差异(P>0.05)。结论:祛痰利肺汤联合噻托溴铵吸入治疗COPE临床疗效好,可减轻患者症状,改善肺功能,降低炎症因子水平,且无显著不良反应发生,安全性良好。

Objective To study the efficacy of combination of Qutan Lifei decoction and tiotropium bromide inhalation in treating patients with chronic obstructive pulmonary disease(COPD).Methods 112 patients with COPD who were treated in the hospital from January 2020 to January 2022 were selected as the research subjects and were randomly divided into control group(n=56)and observation group(n=56).The control group was given tiotropium bromide inhalation therapy while the observation group was treated with Qutan Lifei decoction on the basis of the control group.The clinical efficacy,scores of TCM symptoms,pulmonary function,inflammatory factors and incidence rate of adverse reactions were compared between the two groups.Results After treatment,the scores of various TCM symptoms in the two groups were decreased,and the scores in observation group were significantly lower than the control group(P<0.05).The total effective rate in observation group(98.21%)was higher than that in control group(85.71%)(P<0.05).The tidal volume(VT),total lung capacity(TLC),forced vital capacity(FVC)and the percentage of forced expiratory volume in one second to predicted value(FEV_(1)%pred)in observation group after treatment were significantly higher than those in control group(P<0.05).After treatment,the levels of interferon-γ(IFN-γ)and interleukin-2(IL-2)were significantly lower in observation group compared with those in control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Qutan Lifei decoction combined with tiotropium bromide inhalation has a good clinical efficacy in the treatment of COPE,which can relieve the symptoms,improve the pulmonary function and reduce the levels of inflammatory factors,and it has no significant adverse reactions,with good safety.