血清VEGF、雌激素、IL-6、TNF-α在ROP患儿中的表达水平

Serum levels of VEGF,estrogen,IL-6 and TNF-αin children with retinopathy of prematurity

目的探讨血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、雌激素、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)对早产儿视网膜病变(retinopathy of prematurity,ROP)的影响。方法选取2020年7月至2022年7月于赣州市人民医院诊断为ROP的患儿12例(21眼)纳入ROP组,选择相近矫正胎龄的无ROP早产儿11例纳入非ROP组。比较两组早产儿的血清VEGF、雌激素、IL-6、TNF-α水平。比较接受玻璃体腔抗VEGF药物治疗的7例ROP患儿治疗前后的血清VEGF水平。结果两组早产儿的血清VEGF、雌二醇、IL-6、TNF-α比较差异均无统计学意义(P>0.05),ROP组患儿的出生胎龄显著小于非ROP组,雌三醇显著低于非ROP组(P<0.05)。接受抗VEGF药物玻璃体腔注射治疗的ROP患儿术后1d、7d的血清VEGF水平显著低于治疗前(P<0.05),术后6周与治疗前的VEGF水平比较差异无统计学意义(P=0.351),玻璃体腔注射抗VEGF药物总剂量与血清VEGF水平无显著相关性(r=–0.076,P=0.872)。结论血清VEGF、雌激素、IL-6、TNF-α水平可能对ROP的形成无促进作用,抗VEGF药物玻璃体腔注射对血清VEGF水平有短暂影响。

Objective To investigate the levels of serum vascular endothelial growth factor(VEGF),estrogen,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)on retinopathy of prematurity(ROP).Methods Twelve children(21 eyes)diagnosed with ROP in Ganzhou People’s Hospital from July 2020 to July 2022 were included in ROP group,and 11 premature infants without ROP with similar corrected gestational age were included in non-ROP group.The levels of serum VEGF,estrogen,IL-6 and TNF-αwere compared between the two groups.The serum VEGF levels of 7 children with ROP were compared before and after treatment with intravitreal injection anti-VEGF drugs.Results There were no significant differences in serum VEGF,estradiol,IL-6,and TNF-αbetween the two groups(P>0.05).The gestational age at birth in ROP group was significantly lower than that in non-ROP group,and estriol was significantly lower than that in non-ROP group(P<0.05).The serum VEGF levels of ROP children treated with intravitreal injection anti-VEGF drugs 1 day and 7 days after operation were significantly lower than those before treatment(P<0.05),but there was no significant difference between 6 weeks after operation and before treatment(P=0.351).There was no significant correlation between the total dose of anti-VEGF drugs injected into the vitreous and serum VEGF level(r=-0.076,P=0.872).Conclusion Serum levels of VEGF,estrogen,IL-6 and TNF-αmay not promote the formation of ROP,while intravitreal injection of anti-VEGF drugs has a transient effect on serum VEGF levels.