奥曲肽联合兰索拉唑对上消化道出血患者的效果

Hemostatic effect of octreotide combined with lansoprazole in patients with upper gastrointestinal bleeding

目的研究奥曲肽联合兰索拉唑治疗上消化道出血的效果及对血尿素氮(blood urea nitrogen,BUN)/肌酐(creatinine,Cr)值的影响。方法以120例上消化道出血患者作为研究对象,随机分为观察组和对照组,每组60例。所有患者均使用兰索拉唑进行治疗,观察组在此基础上加用奥曲肽。2组患者均治疗2周,比较2组治疗效果、临床指标、BUN、Cr、BUN/Cr值及不良反应发生情况的差异。结果观察组患者的治疗总有效率(91.67%)显著高于对照组(78.33%)(χ^(2)=3.241,P=0.000);观察组患者的疼痛消失时间(t=19.178,P=0.000)、止血时间(t=20.704,P=0.000)和住院时间(t=15.209,P=0.000)均显著短于对照组;治疗后,2组患者的BUN(t=3.163,P=0.002)、Cr(t=5.117,P=0.000)和BUN/Cr值(t=24.032,P=0.000)均显著下降,且观察组低于对照组;2组患者恶心、便秘以及腹泻等不良反应的发生率比较差异无统计学意义(P>0.05)。结论奥曲肽联合兰索拉唑治疗上消化道出血,能显著降低BUN/Cr值,止血效果较好。

Objective To study the effect of octreotide combined with lansoprazole on hemostasis and blood urea nitrogen(BUN)/creatinine(Cr)ratio in patients with upper gastrointestinal bleeding.Methods A total of 120 patients with upper gastrointestinal hemorrhage were randomly divided into observation group and control group,with 60 patients in each group.All patients were treated with lansoprazole,and the observation group was additionally treated with octreotide.Patients in both groups were treated for 2 weeks,and the differences in treatment effect,clinical indexes,serum urea nitrogen,creatinine,BUN/Cr and the occurrence of adverse reactions were compared between the 2 groups.Results The total effective rate of the observation group(91.67%)was significantly higher than that of the control group(78.33%),the difference was statistically significant(χ^(2)=3.241,P=0.000).The pain disappearance time(t=19.178,P=0.000),hemostasis time(t=20.704,P=0.000)and hospitalization time(t=15.209,P=0.000)of the observation group were significantly shorter than those of the control group.After treatment,the BUN(t=3.163,P=0.000)of the 2 groups were significantly shorter than those of the control group.The Cr(t=5.117,P=0.000)and BUN/Cr(t=24.032,P=0.000)were significantly decreased.The BUN,Cr,and BUN/Cr of the observation group were lower than those of the control group.There was no significant difference in adverse reactions such as nausea,constipation and diarrhea between the 2 groups.Conclusion The ratio of BUN/Cr decreased significantly and hemostasis was better in patients with upper gastrointestinal bleeding.