苯磺酸左旋氨氯地平联合瑞舒伐他汀对冠心病患者颈动脉血流动力学的影响

Effects of levamlodipine besylate combined with rosuvastatin on carotid hemodynamics in patients with coronary heart disease

目的探究苯磺酸左旋氨氯地平联合瑞舒伐他汀对冠心病患者颈动脉血流动力学及主要不良心脏事件(major adverse cardiovascular events,MACE)发生率的影响。方法选取收治的96例冠心病患者,随机分为对照组和观察组,每组48例。对照组患者给予瑞舒伐他汀治疗,观察组给予苯磺酸氨氯地平联合瑞舒伐他汀治疗。2组均治疗3个月。记录治疗前后2组患者的血压、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、颈动脉系统内径、血流速度、阻力指数、左心室收缩末期内径(left ventricular end-systolic dimension,LVESD)、左心室舒张末期内径(left ventricular end diastolic diameter,LVEDD)和左室射血分数(left ventricular ejection fraction,LVEF)。记录治疗期间患者MACE的发生情况。结果治疗后,观察组的总有效率高于对照组,MACE发生率低于对照组(P<0.05)。2组患者的LVESD和LVEDD均缩短,且观察组短于对照组(P<0.05);LVEF均升高,且观察组高于对照组(P<0.05)。2组患者的血压均降低,且观察组低于对照组(P<0.05)。2组患者IL-6、IL-8和TNF-α的水平均降低,且观察组低于对照组(P<0.05)。2组患者颈动脉内径扩大,颈动脉最大血流速度和最小血流速度均加快,且观察组大(快)于对照组(P<0.05);阻力指数均下降,且观察组低于对照组(P<0.05)。结论苯磺酸左旋氨氯地平联合瑞舒伐他汀治疗冠心病能改善心功能、控制血压、降低炎症反应、改善颈动脉血流动力学、减少MACE的发生。

Objective To explore the effects of levamlodipine besylate combined with rosuvastatin on carotid hemodynamics and incidence of major adverse cardiovascular events(MACE)in patients with coronary heart disease(CHD).Methods A total of 96 patients with CHD admitted to the hospital were enrolled and randomly divided into control group and observation group,48 cases in each group.Patients in control group were treated with rosuvastatin,while those in observation group were treated with levamlodipine besylate and rosuvastatin for 3 months.The blood pressure,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),diameter of carotid system,blood flow velocity,resistance index,left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)before and after treatment and occurrence of MACE during treatment in both groups were recorded.Results After treatment,the total response rate was higher in observation group than in control group,and the incidence of MACE was lower in observation group(P<0.05).After treatment,the LVESD and LVEDD in both groups were decreased,which were shorter in observation group than in control group(P<0.05),while the LVEF in both groups was increased,which was higher in observation group than in control group(P<0.05).After treatment,the blood pressure in both groups was decreased,which was lower in observation group than in control group(P<0.05).After treatment,the levels of IL-6,IL-8 and TNF-αin both groups were decreased,which were lower in observation group than in control group(P<0.05).After treatment,the carotid diameter,carotid maximum blood flow velocity and minimum blood flow velocity in both groups were increased,which were higher in observation group than in control group,and the resistance index in both groups was decreased,which was lower in observation group than in control group(P<0.05).Conclusion The levamlodipine besylate combined with rosuvastatin is beneficial to improving cardiac function control blood pressure,reduce inflammatory response,improve carotid hemodynamics and reduce the occurrence of MACE in CHD patients.