硫酸特布他林联合布地奈德治疗支气管肺炎患儿的疗效

Efficacy of terbutaline sulfate combined with budesonide in treating children with bronchopneumonia

目的评价硫酸特布他林联合布地奈德雾化吸入对支气管肺炎患儿免疫球蛋白、白细胞介素-6(interleukin-6,IL-6)及血清降钙素(procalcitonin,PCT)水平的影响。方法选择支气管肺炎患儿89例,用随机数字表法分为对照组(n=44例,予以布地奈德雾化吸入治疗)和观察组(n=45例,在对照组治疗的基础上联合硫酸特布他林治疗),比较2组的临床疗效和症状体征消失时间;比较2组患儿治疗前后免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)和IL-6及血清PCT水平,比较2组不良反应的发生情况。结果观察组的临床有效率为95.56%,高于对照组的79.55%,且观察组的疗效等级优于对照组(P<0.05);观察组咳嗽、发热、气喘、呼吸困难和肺部干湿啰音等症状和体征消失时间均显著短于对照组(P<0.05);治疗后,观察组患儿IgG、IgA和IgM水平均高于对照组(P<0.05);2组IL-6和PCT均低于治疗前,且不同时间点观察组的IL-6和PCT均低于对照组,存在组间、时间和交互效应(P<0.05);2组不良反应发生率比较差异无统计学意义。结论硫酸特布他林联合布地奈德雾化吸入治疗支气管肺炎患儿的疗效显著,有助于改善患儿的临床症状和体征,提高机体免疫并抑制炎性反应。

Objective To evaluate the effects of terbutaline sulfate combined with budesonide aerosol inhalation on the levels of immunoglobulins,interleukin-6(IL-6)and serum procalcitonin(PCT)in children with bronchopneumonia.Methods 89 children with bronchopneumonia were enrolled and divided into control group(n=44,receiving budesonide aerosol inhalation treatment)and observation group(n=45,combined with terbutaline sulfate on the basis of control group)according to the random number table method.The clinical efficacy and disappearance times of symptoms and signs,the levels of immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),IL-6 and serum PCT before and after treatment and occurrence of adverse reactions were compared between the 2groups.Results The clinical effective rate of 95.56%in observation group was higher than 79.55%in control group,and the efficacy grading was better than that in control group(P<0.05).The disappearance times of symptoms and signs such as cough,fever,wheezing,dyspnea and dry and wet rales in the lungs were significantly shorter in observation group than those in control group(P<0.05).After treatment,the levels of IgG,IgA and IgM in observation group were higher than those in control group(P<0.05).The IL-6 and PCT in both groups were lower than those before treatment,and IL-6 and PCT in observation group at different time points were lower than those in control group,with between-group effect,time-point effect and interaction effect(P<0.05).There was no statistically significant difference in the incidence rates of adverse reactions between the 2 groups.Conclusion Terbutaline sulfate combined with budesonide aerosol inhalation has an obvious efficacy in the treatment of children with bronchopneumonia,and it is helpful to improve the clinical symptoms and signs,enhance the body’s immunity and inhibit the inflammatory response.