血清IL-17、Sortilin及PCSK9水平与老年脑梗死患者颈动脉硬化的关系研究

Study on the relationship between serum interleukin-17,Sortilin and preprotein invertase subtilisin 9 levels and carotid atherosclerosis in elderly patients with cerebral infarction

目的探讨血清白介素-17(IL-17)、分拣蛋白(Sortilin)及前蛋白转化酶枯草溶菌素9(PCSK9)水平与老年脑梗死患者颈动脉硬化的关系。方法选取2020年8月—2022年8月本院老年脑梗死患者109例为研究组,同期健康体检者42例为对照组,检测比较2组及研究组不同动脉粥样硬化斑块性质、不同脑梗死面积的血清IL-17、Sortilin及PCSK9水平,分析血清IL-17、Sortilin及PCSK9水平与老年脑梗死患者颈动脉硬化相关性。结果研究组血清IL-17、Sortilin及PCSK9水平高于对照组(P<0.05);脑梗死不稳定斑块患者血清IL-17、Sortilin及PCSK9水平高于稳定斑块、无斑块患者,脑梗死稳定斑块患者血清IL-17、Sortilin及PCSK9水平高于无斑块患者(P<0.05);大体积脑梗死患者血清IL-17、Sortilin及PCSK9水平高于中等体积、小体积患者,中等体积脑梗死患者血清IL-17、Sortilin及PCSK9水平高于小体积患者(P<0.05);血清IL-17、Sortilin及PCSK9水平与老年脑梗死患者颈动脉硬化成正相关关系(r值分别为0.647、0.711、0.692,P<0.05);IL-17、Sortilin、PCSK9水平是升高为老年脑梗死患者颈动脉硬化的危险因素(P<0.05)。结论血清IL-17、Sortilin及PCSK9水平与老年脑梗死患者颈动脉硬化具有相关性,有望成为预测老年脑梗死发生及评估颈动脉硬化情况的重要血清标志物。

Objective This paper aims to investigate the relationship between carotid atherosclerosis in elderly patients with cerebral infarction and the levels of serum interleukin-17(IL-17),sorting protein(Sortilin),and preprotein invertase sub⁃tilisin 9(PCSK9).Methods A total of 109 elderly patients with cerebral infarction in our hospital from August 2020 to August 2022 were selected as the study group,and 54 healthy people in the same period were selected as the control group.Serum IL-17,Sortilin and PCSK9 levels in different atherosclerotic plaque properties and different cerebral infarction areas were detected and compared between the two groups and the study group,and the correlation between serum IL-17,Sortilin and PCSK9 levels and carotid atherosclerosis in elderly patients with cerebral infarction was analyzed.Results Serum IL-17,Sor⁃tilin and PCSK9 levels in the study group were higher than those in the control group(P<0.05).Serum IL-17,Sortilin and PCSK9 levels in patients with unstable cerebral infarction plaque were higher than those in patients with stable plaque and with⁃out plaque,and serum IL-17,Sortilin and PCSK9 levels in patients with stable cerebral infarction plaque were higher than those in patients without plaque(P<0.05).The serum IL-17,Sortilin and PCSK9 levels in patients with massive cerebral infarction were higher than those in patients with medium and small volume,and the serum IL-17,Sortilin and PCSK9 levels in patients with medium volume cerebral infarction were higher than those in patients with small volume(P<0.05).Serum IL-17,Sortilin and PCSK9 levels were positively correlated with carotid atherosclerosis in elderly patients with cerebral infarc⁃tion(r=0.647,r=0.711,r=0.692,P<0.05).The levels of IL-17,Sortilin and PCSK9 were risk factors for carotid ath⁃erosclerosis in elderly patients with cerebral infarction(P<0.05).Conclusion Serum IL-17,Sortilin and PCSK9 levels are correlated with carotid atherosclerosis in elderly patients with cerebral infarction,which is expected to become an important serum marker to predict the occurrence of elderly cerebral infarction and evaluate carotid atherosclerosis.