新型冠状病毒肺炎的临床研究进展

Clinical research progress of COVID-19

新型冠状病毒病19(COVID-19)引起了一场紧急健康事件,COVID-19患者中呈现明显或者严重临床表现的主要为老年人和患有基础疾病的免疫力低下人群。与其它冠状病毒相比,SARS-CoV-2传染性更强、传播范围更广、更多无症状感染者,在积极干预治疗的情况下致死率相对较低。ACE2受体表达水平与病毒感染相关,ARDS、CRS综合征和机体免疫防御机制崩溃可能是导致患者最终死亡的主要原因。

Coronavirus disease 19(COVID-19)causes an emergency health event,COVID-19 patients show obvious or serious clinical manifestations mainly in the elderly and those with underlying diseases.Compared with other coronaviruses,SARS-CoV-2 is more infectious,wider transmission range,more asymptomatic infections and lower mortality rate under active intervention and treatment.The expression of ACE2 receptor is associated with viral infection.ARDS,CRS syndrome and collapse of immune defense may be the main causes of death.