水飞蓟宾靶向结直肠癌肿瘤微环境作用机制研究进展

Research progress on mechanism of Silibinin targeting colorectal cancer microenvironment

肿瘤微环境是指围绕在肿瘤细胞周围的细胞和理化成分,其改变与肿瘤的侵袭、转移及耐药有关。与肿瘤细胞相比,肿瘤微环境中的非肿瘤成分具有更好的遗传稳定性。水飞蓟宾能够在肿瘤的不同阶段发挥抗肿瘤作用,在结直肠癌的研究中引起了广泛关注。从血管生成、炎症反应、免疫细胞、细胞外基质以及肿瘤相关成纤维细胞等方面综述水飞蓟宾对结直肠癌肿瘤微环境的靶向作用,以期为结直肠癌的治疗提供参考。

Tumor microenvironment refers to the cells and physicochemical components surrounding tumor cells,whose changes are associated with tumor invasion,metastasis,and drug resistance.Non-tumor components in the tumor microenvironment have better genetic stability than tumor cells.Silibinin has been found to exhibit anti-tumor effects at different stages of tumors and has attracted widespread attention in colorectal cancer research.This article provides a comprehensive review of the targeted action of Silibinin on the tumor microenvironment of colorectal cancer in terms of angiogenesis,inflammatory response,immune cells,extracellular matrix and tumor-associated fibroblasts,aiming to provide references for the treatment of colorectal cancer.