芳香烃受体调节肠道免疫功能的研究进展

Research Progress of Aryl Hydrocarbon Receptor on RegulatingIntestinal Immune Function

芳香烃受体(AhR)是一种配体激活的转录因子,能够被环境污染物、饮食、微生物和代谢产物激活,参与机体代谢、免疫调节和稳态维持等生理过程。AhR在肠道多种免疫细胞中表达,通过调节上皮内淋巴细胞、固有淋巴细胞、辅助性T细胞17/调节性T细胞和巨噬细胞等免疫细胞的分化和功能,维持肠道免疫和稳态。本文综述了AhR的经典和非经典通路、常见配体及其对肠道免疫功能的调节作用机制,为利用AhR信号通路调节畜禽肠道健康和开发新的免疫治疗方法提供参考。

Aryl hydrocarbon receptor(AhR)is a ligand-activated transcription factor mainly activated by environmental pollutants,diets,microorganisms and metabolites.Studies have shown that AhR is expressed in various immune cells and plays an important role in maintaining intestinal immunity and homeostasis by regulating the differentiation and function of intestinal epithelial lymphocytes,innate lymphoid cells,helper T 17/regulatory T cells and macrophages.This review discusses the classical and non-classical pathways of AhR,common ligands and their regulatory effects on intestinal immunity,providing a theoretical basis for using AhR signaling pathway to regulate intestinal health of livestock and poultry and the development of new immunotherapeutic approaches.