非酒精性脂肪性肝病的心血管疾病相关风险研究进展

Research Progress in Risk of Cardiovascular Disease in Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)是一种可影响全身多个脏器与系统的多因素疾病,与心血管疾病(CVD)的发生有密切联系。NAFLD可增加冠心病、瓣膜性心脏病、心功能不全、心律失常等CVD事件的发生风险,且独立于传统的心脏代谢危险因素。NAFLD与CVD之间关联的可能机制包括遗传易感性、胰岛素抵抗、血栓形成风险增加、动脉粥样硬化性血脂异常、氧化应激和全身炎症反应等。提高临床医师对NAFLD的认识,早期识别NAFLD患者并加强管理,对CVD的发生有较好的预防作用。

Non-alcoholic fatty liver disease(NAFLD)is a multifactorial disease that can affect a variety of organs and systems of the whole body,and has a close relationship with the occurrence of cardiovascular disease(CVD).NAFLD can increase the risk of coronary heart disease,valvular heart disease,cardiac dysfunction,arrhythmia and other CVD events,independent of traditional cardiometabolic risk factors.Possible mechanisms for the association between NAFLD and CVD include genetic susceptibility,insulin resistance,high risk of thrombosis,atherosclerotic dyslipidemia,oxidative stress and systemic inflammatory responses.Raising the the clinicians′awareness of NAFLD and realizing early identification and management of NAFLD patients have a good preventive effect on the occurrence of CVD.