非梗阻性无精子症的激素治疗研究进展

Research Progress of Hormonal Therapy for Non-obstructive Azoospermia

非梗阻性无精子症(NOA)是男性不育症中最严重的一种类型,严重影响男性生殖健康,其特征为睾丸功能衰竭、精子发生障碍、性功能减退等。随着显微外科取精技术的发展,部分NOA患者获得生物学子代。在显微外科取精术前使用促性腺激素、选择性雌激素受体调节剂、芳香化酶抑制剂等药物进行激素治疗可提高NOA患者的获精率,为患者提供个体化诊疗方案可能是今后的研究方向。深入研究激素治疗与精子生成的作用靶点及调控的关系,可为NOA的治疗提供新思路。

Non-obstructive azoospermia(NOA)is the most serious type of male infertility,which seriously affects male reproductive health and is characterized by testicular failure,spermatogenesis obstacles,hypogonadism and so on.With the development of microsurgical sperm retrieval technology,some patients with NOA can obtain biological offspring.Hormonal therapy with drugs such as gonadotropins,selective estrogen receptor modulators,aromatase inhibitors before microsurgical sperm extraction can improve the sperm retrieval rate of the patients.Providing an individualized diagnosis and treatment plan for each patient may be the future research direction.In-depth study of the relationship of hormonal therapy with the target and regulation of spermatogenesis may provide new ideas for the treatment of NOA.