CC趋化因子配体2在创面愈合中的作用研究进展

Research Progress of Role of Chemokine C-C Motif Ligand 2 in Wound Healing

CC趋化因子配体2(CCL2)是CC趋化因子亚家族的重要成员,被认为是调节单核细胞/巨噬细胞迁移和浸润的关键趋化因子。CCL2主要通过与靶细胞膜表面受体CC趋化因子受体2结合,发挥多种生物学作用。由糖尿病、感染等引起的慢性伤口不仅给社会医疗体系带来巨大的压力,而且严重影响患者的身心健康,因此如何更快、更有效地促进创面愈合是目前临床亟须解决的难题。其中,CCL2能有效地促进创面愈合,尤其在细胞趋化、细胞增殖迁移、血管生成、胶原合成及干细胞分化等方面发挥重要作用。因此,未来深入研究CCL2在创面愈合中的作用及机制对治疗慢性难愈性创面具有重要意义。

Chemokine(C-C motif)ligand 2(CCL2)is an important member of the CC-chemokine subfamily and is considered to be a key chemokine regulating monocyte/macrophage migration and infiltration.CCL2 plays a variety of biological roles mainly by binding to target cell membrane surface receptor CC-chemokine receptor 2.Chronic wounds caused by diabetes and infection not only bring great pressure to the social medical system,but also seriously affect the physical and mental health of the patients.Therefore,how to promote wound healing quickly and effectively is a difficult problem that needs to be solved clinically at present.CCL2 can effectively promote wound healing,especially plays important roles in cell chemotaxis,cell proliferation and migration,angiogenesis,collagen synthesis and stem cell differentiation.Therefore,further study on the role and mechanism of CCL2 in wound healing is of great significance for the treatment of chronic refractory wounds in the future.