动脉粥样硬化性心血管疾病的慢性炎症机制及抗炎治疗研究进展

Research Progress in Chronic Inflammatory Mechanism and Anti-inflammatory Therapy of Atherosclerotic Cardiovascular Diseases

动脉粥样硬化性心血管疾病(ASCVD)是影响全球人类健康以及导致人口死亡的首要原因,炎症反应贯穿动脉粥样硬化(As)发生发展的始终,与不良心血管事件的发生密切相关。随着对ASCVD炎症相关性及其机制的不断深入研究,近年已明确As斑块的细胞特征和众多促炎性细胞因子类型是不良心血管事件的独立预测因子,且ASCVD的抗炎治疗探索也逐渐实现临床转化。因此,从炎症角度出发识别急性心血管事件不良预后高危人群,并进行有效综合防治具有重要的临床价值。

Atherosclerotic cardiovascular disease(ASCVD)is the leading cause of global human health and death.Inflammatory reaction runs through all stages of atherosclerosis(As)and is closely related to adverse cardiovascular events.With the continuous in-depth study on the inflammatory correlation and mechanism of ASCVD,it has been confirmed in recent years that the cellular characteristics of As plaque and many types of proinflammatory cytokines are independent predictors of adverse cardiovascular events,and the exploration of anti-inflammatory treatment of ASCVD has gradually achieved clinical transformation.Therefore,it is of great clinical value to identify high-risk population with adverse prognosis of acute cardiovascular events from the perspective of inflammation and to conduct effective comprehensive prevention and treatment.