动脉粥样硬化相关诊断生物标志物的研究进展

Research Progress in Diagnostic Biomarkers Related to Atherosclerosis

动脉粥样硬化(As)作为急性心脑血管事件发生的重要病因,常规筛查方式(超声、CT和磁共振成像等)均有一定局限性。近年研究认为,血浆生物标志物参与了As发展的病理生理过程,从而影响了As进展的不同阶段。因此,深入探讨As的最新生物标志物,尤其是对外分泌体和趋化因子等基因分子层面的研究,可能有助于弥补As常规筛查技术的不足,甚至能够对高危As患者及易损斑块进行分类,为研究As的发病机制、寻找新的诊断指标和治疗靶点提供方向。

Atherosclerosis(As)is an important cause of acute cardiovascular and cerebrovascular events,and routine screening methods such as ultrasound,CT and magnetic resonance imaging all have certain limitations.Recent studies suggested that plasma biomarkers are involved in the pathophysiological process of As development,thus affecting the different stages of As progression.Therefore,further exploration of the new biomarkers of As,especially the study of exosome and chemokines on genetic molecular level,may help to supplement the shortcomings of routine screening techniques for As,and even classify high-risk As patients and vulnerable plaques and provide direction for studying the pathogenesis of As and finding new diagnostic indicators and therapeutic targets.