肥胖型哮喘的发病机制及治疗策略

Pathogenesis and Treatment Strategy of Obese Asthma

肥胖与哮喘的发生发展存在一定关系,肥胖作为哮喘患病的主要危险因素之一,可促进哮喘的发生发展并影响哮喘的病情控制。肥胖型哮喘是一种新的哮喘表型,具有临床症状重、哮喘控制差和常规药物治疗不敏感等特点。目前,肥胖型哮喘的发病机制及其对器官-器官、细胞和分子间的相互作用关系尚不清楚,严重局限了其治疗思路。通过系统阐释临床及动物研究在肥胖型哮喘方面的进展及认知将为深入研究其发病机制及治疗策略开辟更广阔的视野。

Obesity has a certain relationship with the occurrence and development of asthma.As one of the main risk factors of asthma,obesity can promote the occurrence and development of asthma and affect the disease control of asthma.Obese asthma is a new asthma phenotype,which has the characteristics of severe clinical symptoms,poor asthma control and insensitivity to conventional drug therapy.At present,the pathogenesis of obese asthma and its interaction with organ-organ,cells and molecules are still unclear,which severely limits its treatment ideas.The systematic interpretation of the progress and cognition of clinical and animal research in obese asthma will open up a broader vision for in-depth study of its pathogenesis and treatment strategies.