子宫内膜微生物群在辅助生殖技术中的研究进展

Research Progress of Endometrial Microbiota in Assisted Reproductive Technology

基因组学和高通量测序技术的发展推动了人们对人体细菌定植的研究,子宫内膜也有细菌定植。辅助生殖技术(ART)是治疗不孕症的主要手段之一,但目前国内大多数生殖中心胚胎移植临床妊娠率仍较低,因此提高临床妊娠率是生殖中心亟须解决的重大挑战之一。胚胎质量、子宫内膜容受性、子宫内膜微环境是影响胚胎着床主要的因素,但目前关于子宫内膜核心微生物群的组成以及干扰胚胎着床的机制尚未达成共识。因此,未来深入研究子宫内膜微生物群在ART中的作用机制,可以为改善不孕症患者妊娠结局提供新思路。

The development of genomics and high-throughput sequencing technology has promoted the research on bacterial colonization of human body,and the endometrium also has bacterial colonization.Assisted reproductive technology(ART)is one of the main methods to treat infertility,but the clinical pregnancy rate of embryo transfer is still low in most reproductive centers in China.Therefore,improving the clinical pregnancy rate is one of the major challenges to be solved urgently in reproductive centers.Embryo quality,endometrial receptivity and endometrial microenvironment are the main factors affecting embryo implantation.However,there is no consensus on the composition of the core endometrial microbiota and the mechanism of how it interferes with embryo implantation.Therefore,in-depth studies of the mechanisms of endometrial microbiota in ART in the future could provide new ideas for improving pregnancy outcomes in infertile patients.