黄芪治疗癌因性疲乏的作用机制

Mechanism of Action of Astragalus in Treating Cancer-related Fatigue

癌因性疲乏(CRF)是肿瘤常见并发症之一,发病率高,严重影响患者生活质量。黄芪作为“补气之最”,在CRF的治疗中已取得一定进展。黄芪以甘温扶阳、建复中气、补益脾胃、补益气血等中医思想为指导,通过减轻肿瘤负荷改善疲乏状态,并通过调节细胞因子和免疫功能、皮质醇和下丘脑-垂体-肾上腺轴、骨骼肌和线粒体功能以及心理状态等治疗CRF。因此,深入探讨黄芪治疗CRF的作用机制可以为新药开发、中西医临床应用提供新思路。

As one of the common complications of tumors,cancer-related fatigue(CRF)has a high incidence and seriously affects the quality of life of the patients.Astragalus,as the"best herb for invigorating qi",has made a certain progress in treating CRF.Astragalus guidedby the traditional Chinese medicine thoughts of sweetness and warm to assist yang,restorage of middle-jiao qi,tonifying the spleen and stomach,and tonifying qi and blood to reduce tumor load and improve fatigue state,as well as regulating cytokines and immune function,regulating cortisol and hypothalamic-pituitary-adrenal axis,regulating skeletal muscle and mitochondrial function,regulating mental state etc.,to treat CRF.Therefore,deeper exploration of the mechanism of Astragalus in the treatment of CRF can provide new ideas for the development of new drugs and the clinical application of Chinese and western medicine.