摘要
Tumor-associated lymphangiogenesis is thought to be an importantmetastaticstepin intrahepaticccholangiocarcinoma(ICC),while the origin of tumor-associated lymphatic vessels within tumors is little known.Cancerassociated fibroblasts(CAFs)enhance tumor progression through many aspects.2 CAFs have been discovered exhibiting cellular plasticity of phenotypic transition-such as epithelial-mesenchymal transition(EMT)which promotes increased migratory and invasive capabilities of cells.3However,mesenchymal-to-endothelial,(MEndT)transition is yet to be identified in tumor entities.
基金
supported by the National Natural Science Foundation of China(No.81902379)
Cultivation Foundation of Renji Hospital,Shanghai,China(No.RJPY-LX-011)
National Key Research on Precision Medicine of China(No.2018ZX10723204).