摘要
Severe acute respiratory syndrome coronavirus-2(SARSCoV-2),which causes coronavirus disease 2019(COVID-19)and initially infects epithelial cells of the upper respiratory tract,has recently caused a global health emergency and is still a potential threat to humans.1 Multiple studies have suggested alterations in the immune system,including excessive neutrophil activation and lymphopenia,and excessive inflammatory responses as the key mechanisms for severesymptoms.2However,which cell types contribute to excessive inflammation remains to be explored.Further analysis of human blood immune cells provides insights into the coordinated response to SARSCoV-2 infections and is a significant task for restraining the virus and controlling disease progression.
