针刺疗法治疗失眠的机制

Mechanism of Acupuncture Therapy for Insomnia

失眠症的临床发病率极高,严重影响患者的身心健康和生活质量。针刺作为中医治疗手段之一,在治疗失眠症方面疗效显著,但具体作用机制目前尚未完全阐明。针刺治疗失眠所干预的目标主要包括神经递质(如5-羟色胺、去甲肾上腺素、多巴胺、γ-氨基丁酸、谷氨酸、一氧化氮)、细胞因子、褪黑素、生物钟基因、下丘脑-垂体-肾上腺轴等,但目前尚未形成系统的理论体系。因此,未来仍需深入研究针刺治疗失眠的相关机制,为临床失眠症的治疗提供有力的理论支持。

The clinical incidence of insomnia is extremely high,which seriously affects the patients′physical and mental health,and the quality of life.As one of the treatments of Chinese medicine,acupuncture has remarkable curative effect in the treatment of insomnia,but the specific mechanism of action has not been fully elucidated.The targets of acupuncture therapy for insomnia mainly include neurotransmitters(e.g.5-hydroxytryptamine,norepinephrine,dopamine,γ-aminobutyric acid,glutamic acid,nitric oxide),cytokines,melatonin,clock genes,hypothalamic-pituitary-adrenal axis,etc.,but no systematic theoretical system has been formed.Therefore,it is necessary to further study the relevant mechanisms of acupuncture in the treatment of insomnia in the future,so as to provide strong theoretical support for the treatment of clinical insomnia.