慢性阻塞性肺疾病并发肺癌的分子机制研究进展

Research Progress in Molecular Mechanism of Chronic Obstructive Pulmonary Disease Complicated with Lung Cancer

慢性阻塞性肺疾病(COPD)和肺癌是密切相关的两种疾病,严重威胁人类健康。COPD和肺癌的流行病学联系紧密,相同的高危因素以及发病机制是COPD并发肺癌的关键。慢性炎症通过细胞外基质降解、上皮-间充质转化、血管生成和增殖等参与COPD向肺癌的转化。此外,氧化应激、免疫调节及遗传易感性等机制也可破坏肺实质和肺血管,诱发DNA损伤、细胞凋亡、组织异常修复,甚至促进肿瘤细胞逃逸和侵袭转移。因此,未来进一步深入探索COPD并发肺癌的分子机制,可以为临床寻求特异性诊断标志物、开发新的治疗策略提供理论依据。

Chronic obstructive pulmonary disease(COPD)and lung cancer are two closely related diseases that seriously threaten human health.The epidemiology of COPD and lung cancer is closely related,and the common risk factors and pathogenesis are the key of COPD complicated with lung cancer.Chronic inflammation is involved in the transformation of COPD to lung cancer through extracellular matrix degradation,epithelial mesenchymal transformation,angiogenesis and proliferation.Besides,oxidative stress,immune regulation,genetic susceptibility and other mechanisms can also destroy lung parenchyma and pulmonary vessels,induce DNA damage,cell apoptosis,abnormal tissue repair,and even promote the invasion and metastasis of tumor cells.Therefore,the future exploration of the molecular mechanism of COPD complicated with lung cancer will provide theoretical basis for seeking specific clinical diagnostic markers and developing new treatment strategies.