长链非编码RNA HOTAIR在结直肠癌中的研究进展

Research Progress of Long Non-coding RNA HOTAIR in Colorectal Cancer

结直肠癌(CRC)是消化系统常见的恶性肿瘤,也是恶性肿瘤患者死亡的主要原因之一。近年来我国CRC的发病率和病死率不断升高,迫切需要寻找更有效的治疗策略。HOX转录物反义RNA(HOTAIR)是长链非编码RNA(lncRNA)家族中的一员,在CRC细胞和组织中均高表达,并可作为原癌基因通过多种途径调控CRC细胞的增殖、侵袭、迁移、凋亡以及耐药等,与CRC的发生发展密切相关。因此,深入研究lncRNA HOTAIR在CRC发生发展中的作用机制,可以为CRC的治疗提供新思路。

Colorectal cancer(CRC),a common malignant tumor in the digestive system,is one of the main causes of death in patients with neoplasia.In recent years,the incidence and mortality of CRC have continued to rise in China,and there is an urgent need to find more effective treatment strategies.HOX transcript antisense RNA(HOTAIR),as a member of long non-coding RNA(lncRNA)family,is highly expressed in colorectal cancer cells and tissues.As a proto-oncogene,HOTAIR,which can regulate the proliferation,invasion,migration,apoptosis and drug resistance of CRC cells in several ways,is closely related to the occurrence and development of CRC.Therefore,an in-depth study of the mechanism of lncRNA HOTAIR in the occurrence and development of CRC can provide new ideas for the treatment of CRC.